Dimitris K. Agrafiotis is Vice President of Informatics at Johnson & Johnson Pharmaceutical Research & Development. He also serves as Adjunct Professor of Informatics at Indiana University School of Informatics and the University of Athens School of Pharmacy. After finishing his undergraduate studies in chemistry in Greece, he moved to Imperial College, University of London, where he received his Ph.D. in theoretical organic chemistry under the directions of Prof. H. Rzepa. Following post-doctoral training with Prof. A. Streitwieser at the University of California, Berkeley, and Nobel laureate Prof. E. J. Corey at Harvard, he joined Parke-Davis Pharmaceutical Research (now Pfizer) as a Senior Scientist in the Computer-Aided Drug Design group. In 1994, he moved to 3-Dimensional Pharmaceuticals (3DP) where he focused on the development of intelligent computational tools for combinatorial chemistry and structure-based drug design, serving as Executive Director of Informatics. Following the acquisition of 3DP by Johnson & Johnson PRD in 2003, he was appointed Senior Research Fellow and Team Leader of the Molecular Design and Informatics group at the US Research & Early Development site, and directed the development of ABCD, a new global informatics platform for J&J PRD (see also Nature Rev. Drug Discov. 2007, BioIT World 2006, and BioIT World 2007). In his current role, he oversees all information management systems for research & early development worldwide, and is responsible for setting global information technology strategy and architecture for J&J pharmaceutical R&D. He also directed the ERIS program, a global regulatory information management system aimed at harmonizing electronic submissions to the health authorities around the world, and is actively involved in the development of a new generation of informatics solutions to support clinical, epidemiological, and translational research. His research spans many areas of computational chemistry and biology, including computer-assisted drug design, chemo- and bioinformatics, data mining, visualization, artificial intelligence and software engineering. He is the author of 80 scientific publications and book chapters, and co-inventor of 18 patents. He serves on the Editorial Boards of the Journal of Chemical Information and Modeling, Molecular Informatics, Chemical Biology & Drug Design, Journal of Molecular Graphics and Modeling, and Molecular Diversity, the Boards of the International QSAR & Modeling Society and the Chemical Structure Association Trust, and the Scientific Advisory Boards of the NIH Exploratory Centers for Chemoinformatics Research at Indiana University, University of North Carolina, and Rensselaer Polytechnic Institute, as well as the Environmental Bioinformatics and Computational Toxicology Center at Rutgers University. He frequently delivers invited lectures, serves as symposium organizer at national and international conferences, and participates in grant review boards.